The National Animal Genome Research Program (NAGRP), NRSP-8, has been hugely successful, exceeding all expectations, by helping to deliver complete genome sequences of pig, cattle, sheep, goat, horse, chicken and turkey and providing genetic tools and resources that have revolutionized the animal breeding industry. These successes, along with concomitant advances in genomics-enabled technologies, resulted in the release of the 2018-2027 USDA Animal Genome Blueprint (1) which outlines key areas for future research and funding.