| QTL Map Information |
|---|
| Chromosome: | 3 |
| QTL Peak Location: | n/a |
| QTL Span: | n/a
37.0-37.0 (Mbp) |
 |
Upper, "Suggestive": | n/a |
| Upper, "Significant": | n/a |
| Peak: | rs68458866 |
| Lower, "Significant": | n/a |
| Lower, "Suggestive": | n/a |
| Marker type: | SNP |
| Analysis type: | Association |
| Model tested: | - |
| Test base: | Comparison-wise |
| Threshold significance level: | Significant |
 |
P_values | 4.71E-7 | | Dominance effect: | n/a |
| Additive effect: | n/a |
| Associated Gene: | MC1R (melanocortin 1 receptor) |
| Cis/Trans acting type: |  |
| Links:
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| QTL Experiment in Brief |
|---|
| Animals: | Two stallions with a heritable white spotting pattern with unknown genetic cause, one Arabian and one Mangalarga, were used. Phenotype scoring was performed on an additional 147 horses of unspecified breeds. |
| Breeds associated:
n/a
|
| Design: | The coding regions of the KIT and MITF genes were subjected to targeted exon sequencing to identify variants that could be associated with the white spotting phenotype. A candidate KIT mutation and SNPs in MC1R and ASIP were analyzed for association with degree of white spotting. |
| Analysis: | A multiple linear regression model was used. |
| Software: | Haploview v4.1, SAS JMP Pro v15 |
| Notes: | |
| Links: | Edit |
| Reference |
|---|
| Authors: | Patterson Rosa L, Martin K, Vierra M, Lundquist E, Foster G, Brooks SA, Lafayette C |
| Affiliation: | Etalon, Inc., Menlo Park, CA 94025, USA |
| Title: | A KIT Variant Associated with Increased White Spotting Epistatic to MC1R Genotype in Horses (Equus caballus) |
| Journal: | Animals : an open access journal from MDPI, 2022, 12(15):1958 |
| Links: |
PubMed | Abstract | List all data
| Edit |
| Additional Information |
|---|
| Comments: | MC1R Extension |
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QTL315883