Lykkjen S, Dolvik N I, McCue M E, Rendahl A K, Mickelson J R, Røed K H
(Contact: sigrid.lykkjen@nvh.no)
Affiliation:
Department of Basic Sciences and Aquatic Medicine, The Norwegian School of Veterinary Science, Post-box 8146 Dep., N-0033, Oslo, Norway; Department of Companion Animal Clinical Sciences, Section for Equine Medicine and Surgery, The N
Title:
Equine developmental orthopaedic diseases--a genome-wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters
Palmar/plantar osteochondral fragments (POF) in fetlock joints commonly affect and influence the athletic performance of horses. In this study, we used the Equine SNP50 BeadChip® to perform a genome-wide association study of metatarsophalangeal POF in 176 Norwegian Standardbred trotter yearlings. Putative quantitative trait loci (QTL) for medial and/or lateral POF, and medial POF only were identified on ECA1, 2, 7, 9 and 31, whereas for lateral POF, only on ECA7, 11, 27 and X. The moderate number of QTL evidences a complex inheritance and suggests various genes controlling POF development in medial and lateral locations.
