Orr N, Hill E W, Gu J, Govindarajan P, Conroy J, van Grevenhof E M, Ducro B J, van Arendonk J A M, Knaap J H, van Weeren P R, Machugh D E, Ennis S, Brama P A J
(Contact: Pieter.Brama@ucd.ie)
Affiliation:
Animal Genomics Laboratory, School of Agriculture and Food Science, University College Dublin, Dublin, Ireland; Section of Veterinary Clinical Sciences, School of Veterinary Medicine, University College Dublin, Dublin, Ireland
Title:
Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10
Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).
