Release 56
(Apr 24, 2025)

QTL 37312 Description:

 Trait Information
Trait name: M. paratuberculosis susceptibility Vertebrate Trait Ontology: n/a
Reported name: M. paratuberculosis susceptibility Product Trait Ontology: n/a
Symbol: MPARA Clinical Measurement Ontology: Disease process measurement
 QTL Map Information
Chromosome:4
QTL Peak Location:50.38 (cM)
QTL Span:50.38-50.38 (cM)
51.1-51.1 (Mbp)
Upper, "Suggestive":n/a
Upper, "Significant":n/a
Peak:rs43390642
Lower, "Significant":n/a
Lower, "Suggestive":n/a
Marker type:SNP
Analysis type:Association
Model tested:Mendelian
Test base:n/a
Threshold significance level:Significant
P_values0.043
Dominance effect:n/a
Additive effect:n/a
Associated Gene:WNT2 (wingless-type MMTV integration site family member 2)
Cis/Trans acting type:
Links:   NCBI GeneDB  |  Edit  |   Map view

 Extended information:
(none)

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  •  QTL Experiment in Brief
    Animals:Animals were German Holstein cattle.
     Breeds associated:
    Design:In this confirmation study, animals were genotyped for four SNPs in regions previously identified as associated with MAP resistance/susceptibility and analyzed for susceptibility to paratuberculosis.
    Analysis:Fisher's exact test was used.
    Software:POPGENE, SAS, Haploview
    Notes: 
    Links:Edit

     Reference
    Authors:Pauciullo A, Küpper J, Brandt H, Donat K, Iannuzzi L, Erhardt G
    Affiliation:Laboratory of Animal Cytogenetics and Gene Mapping, National Research Council (CNR) of Italy, ISPAAM, via Argine 1085, 80147, Naples, Italy; Institute for Animal Breeding and Genetics, Justus-Liebig University, Ludwigstrasse 21 B, 35
    Title:Wingless-type MMTV integration site family member 2 (WNT2) gene is associated with resistance to MAP in faecal culture and antibody response in Holstein cattle
    Journal:Animal genetics, 2015, 46(2): 122-132
    Links:  PubMed  |  Abstract   |  List all data   |  Edit  

     Additional Information
    Comments:ELISA or fecal positive/negative
    User inputs on reference #25643727
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  • Cite this Data:

    Animal QTLdb: QTL37312 was published in 2015, and was curated into QTLdb on 2015-03-18. DBxREF link to this data: https://www.animalgenome.org/QTLdb/q?id=QTL_ID:37312

     

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