Release 56
(Apr 24, 2025)

QTL 18824 Description:

 Trait Information
Trait name: M. paratuberculosis susceptibility Vertebrate Trait Ontology: n/a
Reported name: M. paratuberculosis susceptibility Product Trait Ontology: n/a
Symbol: MPARA Clinical Measurement Ontology: Disease process measurement
 QTL Map Information
Chromosome:17
QTL Peak Location:5.2 (cM)
QTL Span:5.12-5.41 (cM)
3.9-4.1 (Mbp)
Upper, "Suggestive":n/a
Upper, "Significant":n/a
Peak:
Lower, "Significant":n/a
Lower, "Suggestive":n/a
Marker type:
Analysis type:Association
Model tested:Mendelian
Test base:Experiment-wise
Threshold significance level:Significant
P_values<0.05
Dominance effect:n/a
Additive effect:n/a
Associated Gene:TLR2 (toll-like receptor 2)
Cis/Trans acting type:
Links:   NCBI GeneDB  |  Edit  |   Map view

 Extended information:
(none)

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  •  QTL Experiment in Brief
    Animals:Animals were Holstein-Friesian cattle.
     Breeds associated:
    Design:Animals were genotyped for 24 SNP in TLR1, TLR2, and TLR4 and analyzed for MAP infection status.
    Analysis:Association analysis was carried out under five different genetic models simultaneously: codominant, dominant, recessive, overdominant, and log-additive.
    Software:SPSS, R, Haploview
    Notes: 
    Links:Edit

     Reference
    Authors:Ruiz-Larranaga O, Manzano C, Iriondo M, Garrido JM, Molina E, Vazquez P, Juste RA, Estonba A
    Affiliation:Genetics, Physical Anthropology and Animal Physiology Department, University of the Basque Country, UPV/EHU, Sarriena s/n, 48940 Leioa, Bizkaia, Spain
    Title:Genetic variation of toll-like receptor genes and infection by Mycobacterium avium ssp. paratuberculosis in Holstein-Friesian cattle
    Journal:J Dairy Sci, 2011, 94(7):3635-41
    Links:  PubMed  |  Abstract   |  List all data   |  Edit  
    User inputs on reference #21700053
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  • Cite this Data:

    Animal QTLdb: QTL18824 was published in 2011, and was curated into QTLdb on 2012-12-13. DBxREF link to this data: https://www.animalgenome.org/QTLdb/q?id=QTL_ID:18824

     

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