Qin C, Yin H, Zhang X, Sun D, Zhang Q, Liu J, Ding X, Zhang Y, Zhang S
(Contact: zhangslcau@cau.edu.cn)
Affiliation:
College of Animal Science and Technology, Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory of Animal Breeding, China Agricultural University, Beijing 100193, China
Title:
Genome wide association study for semen production traits in Holstein bull population in China
Journal:
Animal Genetics, 2016,
DOI:
(n/a)
Abstract:
In this paper, a genome-wide association study (GWAS) was performed to identify the markers and candidate genes for five semen production traits in the Holstein bull population in China. The analyzed data set consisted of 692 bulls from 8 bull stations and each bull was genotyped using the Illumina BovineSNP50 Beadchip. Association test between each trait and the 41,188 informative high-quality SNPs were achieved with GAPIT software. In total, 21 suggestive significant SNPs associated with five semen production traits were detected, which were partly located within the reported QTL regions and others were within or close to the reported candidate genes. By combining with our GWAS results and the biological functions of these genes, 8 novel promising candidate genes were suggested to potentially relate to semen production traits, including ETNK1, PDE3A, PDGFRB, CSF1R, WT1,DSCAML1, SOD1, and RUNX2. Our findings may provide a basis for further research on the genetic mechanism of semen production and marker assisted selection of such traits in Holstein bulls.
