Release 56
(Apr 24, 2025)

Reference # 24304010 Details:

Authors:Kim Y, Ryu J, Lee C (Contact: clee@ssu.ac.kr)
Affiliation:Department of Bioinformatics and Life Science, Soongsil University, Seoul, 156-743, South Korea.
Title:Replicated association of single-nucleotide marker on chromosome 6 with bovine yearling weight using a mixed model analysis.
Journal:Animal Genetics, 2014, 45(1): 151-3 DOI: 10.1111/age.12110
Abstract:

Genome-wide association studies (GWAS) have been used extensively for identifying nucleotide variants contributing phenotypic variability to complex traits. These studies recently were applied to mapping genetic markers for bovine growth, which is a major concern to the beef industry. Some markers have been identified for carcass weight (ss115546873, ss61544523, ss61534604, P < 1.27 x 10E-6) and eye muscle area (ss86300146, ss86319521, P < 1.28 x 10E-6). In a GWAS with crossbred beef cattle, a number of markers were identified for different body weights. For example, 91 nucleotide variants were associated with yearling weight (P < 1.13 x 10E-6). Difficulties have been experienced when replicating associations for human complex traits in the GWAS4. This problem might be a major obstacle to the use of the genetic markers in improving bovine growth. In this study, we examined replication of the GWAS signals for yearling weight using Korean cattle.

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