Blott S, Kim JJ, Moisio S, Schmidt-Küntzel A, Cornet A, Berzi P, Cambisano N, Ford C, Grisart B, Johnson D, Karim L, Simon P, Snell R, Spelman R, Wong J, Vilkki J, Georges M, Farnir F, Coppieters W.
Affiliation:
Department of Genetics, Faculty of Veterinary Medicine, University of Liege,4000 Liege, Belgium.
Title:
Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosinesubstitution in the transmembrane domain of the bovine growth hormone receptoris associated with a major effect on milk yield and composition.
We herein report on our efforts to improve the mapping resolution of a QTL withmajor effect on milk yield and composition that was previously mapped to bovinechromosome 20. By using a denser chromosome 20 marker map and by exploitinglinkage disequilibrium using two distinct approaches, we provide strong evidencethat a chromosome segment including the gene coding for the growth hormonereceptor accounts for at least part of the chromosome 20 QTL effect. Bysequencing individuals with known QTL genotype, we identify an F to Ysubstitution in the transmembrane domain of the growth hormone receptor genethat is associated with a strong effect on milk yield and composition in thegeneral population.
