QTLdb: entrichment tests

Release 59
(Apr 20, 2026)

Whole genome analysis for QTL/association enrichment

Running...

Version: Enrich S: beta v0.8

Search:	to limit the list of your trait choices:
	(optional) focus on chromosome with Mb windows across its length

Data:

Number of disease traits:	21
Number of QTL / associations found:	7,993
Number of chromosomes where QTL / associations are found:	30

Chi-squared (χ²) test: are disease traits over-represented on some chromosomes?

Chromosomes	Total χ²	df	p-values	FDR ^*	Size of χ²
Chromosome X	4480.89411	29	9e-41	1.000000e-40
Chromosome 1	943.90863	29	6.020095e-180	4.515071e-179
Chromosome 2	909.72231	29	9.710958e-173	5.826575e-172
Chromosome 3	73.00125	29	1.165175e-05	1.205353e-05
Chromosome 4	2289.49560	29	9e-41	1.000000e-40
Chromosome 5	1220.40555	29	1.747574e-238	2.621361e-237
Chromosome 6	1575978.02166	29	9e-41	1.000000e-40
Chromosome 7	2453.53353	29	9e-41	1.000000e-40
Chromosome 8	2594.56701	29	9e-41	1.000000e-40
Chromosome 9	2481.42510	29	9e-41	1.000000e-40
Chromosome 10	717.84531	29	1.851471e-132	9.257355e-132
Chromosome 11	2343.54435	29	9e-41	1.000000e-40
Chromosome 12	3072.35712	29	9e-41	1.000000e-40
Chromosome 13	2594.56701	29	9e-41	1.000000e-40
Chromosome 14	1162.26873	29	3.810727e-226	3.810727e-225
Chromosome 15	2079.60585	29	9e-41	1.000000e-40
Chromosome 16	278.41380	29	1.455799e-42	6.239139e-42
Chromosome 17	2710.23123	29	9e-41	1.000000e-40
Chromosome 18	2481.42510	29	9e-41	1.000000e-40
Chromosome 19	1361.57574	29	1.692240e-268	5.076720e-267
Chromosome 20	200.47776	29	1.511445e-27	1.619405e-27
Chromosome 21	2236.07727	29	9e-41	1.000000e-40
Chromosome 22	2453.53353	29	9e-41	1.000000e-40
Chromosome 23	43.28121	29	0.04287544	4.287544e-02
Chromosome 24	3934.83636	29	9e-41	1.000000e-40
Chromosome 25	2918.71272	29	9e-41	1.000000e-40
Chromosome 26	3326.38530	29	9e-41	1.000000e-40
Chromosome 27	4632.49962	29	9e-41	1.000000e-40
Chromosome 28	2858.35830	29	9e-41	1.000000e-40
Chromosome 29	3103.55892	29	9e-41	1.000000e-40

Chi-squared (χ²) test: Which of the 21 disease traits are over-represented in the QTLdb

Traits	Total χ²	df	p-values	FDR ^*	Size of χ²
Bovine coronavirus susceptibility	385.38315	20	2.186617e-69	7.653159e-69
Bovine leukemia virus susceptibility	712.64155	20	4.674542e-138	3.272179e-137
Bovine respiratory disease susceptibility	1472.20932	20	3.646166e-300	7.656949e-299
Bovine spongiform encephalopathy susceptibility	127.63907	20	1.079242e-17	1.618863e-17
Bovine tuberculosis susceptibility	1842.91525	20	9e-41	1.890000e-40
Bovine viral diarrhea virus susceptibility	451.6859	20	3.628505e-83	1.523972e-82
Cholesterol deficiency	84.03189	20	8.03589e-10	1.054711e-09
Cystic ovaries	139.33848	20	6.756003e-20	1.091354e-19
Dwarfism	32.86861	20	0.03487773	3.487773e-02
Endometritis	64.23604	20	1.543704e-06	1.674789e-06
Epidermolysis bullosa	87.81108	20	1.784889e-10	2.498845e-10
Foot-and-mouth disease susceptibility	472.3374	20	1.775308e-87	9.320367e-87
General disease susceptibility	78.62145	20	6.720519e-09	8.301818e-09
Infectious bovine keratoconjunctivitis susceptibility	205.69606	20	8.37541e-33	1.598942e-32
Ketosis	1030.34993	20	1.311669e-205	1.377252e-204
M. paratuberculosis susceptibility	2040.78474	20	9e-41	1.890000e-40
Marfan syndrome-like disease	70.71085	20	1.393654e-07	1.625930e-07
Metritis	293.24054	20	1.936053e-50	5.808159e-50
Milk fever	1535.78597	20	9e-41	1.890000e-40
Percentage decrease in body weight up to day 150 after challenge	64.14648	20	1.595037e-06	1.674789e-06
Rabies antibody titer	164.52084	20	1.003053e-24	1.755343e-24

Correlations found between some of these traits for your reference

No correlation data found on these traits

Overall Test

Data		Chi'Square Test			Fisher's Exact Test
Number of chrom.:	30	χ²	=	1637934.529980
Number of traits:	21	df	=	580
Number of QTLs:	7,993	p-value	=	0

FOOT NOTE: * : FDR is short for "false discovery rate", representing the expected proportion of type I errors. A type I error is where you incorrectly reject the null hypothesis, i.e. you get a false positive. It's statistical definition is FDR = E(V/R | R > 0) P(R > 0), where V = Number of Type I errors (false positives); R = Number of rejected hypotheses. Benjamini–Hochberg procedure is a practical way to estimate FDR.